The answer is: Esau wanted to kill him

Gen 27:41-44

When Jacob felt the heat of Esau’s wrath, fleeing became his only option. The charged atmosphere in ways reminiscent of earlier biblical themes takes us to the tale of familial friction, much like the story of Cain and Abel. The connection between siblings and rivalry is vividly drawn out not just in Jacob and Esau’s tale but recurs later numerous times throughout scripture.

Esau isn’t just an angry brother here; he symbolizes a primal sense of loss – the bitter struggle that comes when one sibling feels wronged, leaving an emotional and spiritual echo that resonates throughout man’s narratives. Imagine Jacob packing his bags and being keenly aware that this departure from home wouldn’t merely mean a change in location; it would symbolize a hazily conceived quest for redemption, evolution, and eventual reconciliation with his past—how’s that for foreshadowing?

Also intriguing is how he ends up with Laban, the very bustling character whose name means “white.” Laban later becomes a major player, unleashing complications including arranged marriages and even orchestrated trickery of his own. This shift marks the beginning of Jacob's transformative journey—away from deception, yet deep in the heart of it, leading to unforeseen personal development over the vital span of twenty agonizing years.

In essence, Jacob’s flight marks more than escape; it signifies stepping into a grand divine narrative rich with lessons of cunning, calculated moves, and a God who still plays' chess behind the scenes, drawing together blueprints manifested in human interaction.